The Best Glucosamine Chondroitin Supplements to Help Fight Joint Pain in 2024

Everyone is likely to deal with joint pain at some point. Whether it is mild pain or severe arthritis caused by old age or physical activity, research suggests that our joints will wear down, leading to pain and other symptoms that will impact our health and well-being.

For some, this means speaking to a doctor or healthcare provider to obtain anti-inflammatory or pain relief medications. However, while these can lead to less pain, they can also cause side effects, and some can only be used for up to three years before you have to stop taking them entirely.

That is why dietary supplements are usually a better option, as many of them can produce a similar level of effectiveness while being generally considered safe for most people. Perhaps none reflect this more than glucosamine and chondroitin supplements, which have very high levels of efficacy and safety.

The only problem is that with so many nutritional supplements of this kind on the market, it can be hard to know which to use. That is why we have made this guide to the top 10 joint health supplements with glucosamine and chondroitin in 2024, to help everyone find the perfect pain relief option for them.

Reviewing The Best Glucosamine Chondroitin Supplements In 2024

Let's get to our guide to the top 10 joint health supplements with glucosamine and chondroitin in 2024. By comparing many nutritional supplements based on vital criteria like their ingredients, range of effects, effectiveness, and price, we have made a list that features a perfect supplement for everyone.

• Joint Buddy
• FlexAgain
• Glucosamine, Chondroitin, MSM With OptiMSM By Doctor's Best
• Solgar Glucosamine, Hyaluronic Acid, Chondroitin, MSM
• Vimerson Health Vegan Glucosamine Chondroitin MSM & Burdock Root
• Nuzena Joint Support +
• Physio Flex Pro
• Vitapost ProJoint Plus
• Puritan's Pride Triple Strength Glucosamine Chondroitin With Vitamin D
• Animal Flex

Joint Buddy - Best Overall

Joint Buddy is one of the newer joint supplements on our list, but that doesn't make it any less effective. It boasts potent doses of glucosamine and chondroitin and supports them with vitamins, minerals, and other natural anti-inflammatory ingredients proven to improve joint health and relieve pain.

These powerful antioxidant and anti-inflammatory properties improve joint mobility, flexibility, and lubrication, protect and repair the cartilage structure, and enhance bone density and strength. It is very reasonably priced and even offers benefits for other parts of the body.

These additional benefits include improving eye pressure, brain, heart, and immune system health and functions, energy levels, prevention of vitamin and mineral deficiencies, acceleration of body fat loss, and even helping prevent or treat specific diseases.

Ingredients: Vitamin A, vitamin B1, Vitamin B2, Vitamin B3, Vitamin B6, Vitamin B12, vitamin C, Vitamin E, selenium, zinc, copper, boron, manganese, chromium, glucosamine sulfate, chondroitin sulfate, green-lipped sea mussel, MSM, l-histidine, alfalfa powder, yuca, devil's claw, and cetyl myristoleate

Pros

• Uses nothing but potent doses of a wide range of proven, natural ingredients
• Offers benefits beyond just supporting the joints, like improved eye pressure
• Promotes joint health from a vast number of different angles
• The best value joint supplement on the market today

Cons

• As one of the newer joint supplements, past customer reviews are rare
• It has to be purchased directly from the official Joint Buddies website

Conclusion

Joint Buddy may be a relatively new joint supplement, but it is still better than any other chondroitin and glucosamine sulfate supplement we have seen. Packed with potent doses of both compounds, many different ingredients, and reasonably priced, it can genuinely support the joints from every angle.

FlexAgain - Best With Vitamin D

Many consider FlexAgain the best joint supplement on the market today, and it only misses out on the top spot on this list. Packed with optimal doses of a combination of high-quality, natural ingredients with plenty of evidence to show they work, it benefits the joints in countless ways.

Vitamin D prevents vitamin D deficiency, which can lead to pain and poor joint health. Its other anti-inflammatory ingredients boost the health, function, repair, flexibility, mobility, and lubrication of the joints, aid cartilage connective tissue growth and repair, and reduce joint pain and swelling.

The formula works in perfect harmony to be more effective than the sum of its parts, combating arthritis, neutralizing free radicals, and preventing oxidative stress and damage. It falls short of the top spot because it is expensive and unsuitable for people taking blood thinners.

Ingredients: glucosamine sulfate, chondroitin sulfate, omega-3 fatty acids, curcumin extract (turmeric), ginger and blue galangal extracts, bromelain, resveratrol, boswellic acid, MSM (methylsulfonylmethane), vitamin K, and vitamin D

Pros

• The best evidence shows that all its ingredients produce positive joint results.
• Every ingredient is optimally dosed to produce results without causing side effects.
• It can relieve joint pain and improve joint health and functions simultaneously.
• Offers additional health benefits not linked to the joints
• Every purchase comes with a 90-day money-back guarantee

Cons

• One of the pricier joint health supplements
• Only available directly from the official FlexAgain website
• It is not suitable for people who are taking blood thinners

Conclusion

FlexAgain packs an incredible amount into a single supplement, supporting the joints in many ways. While it may not be the right choice for everyone, those who want to reduce pain and improve joint health as quickly as possible will not find a better way.

Doctor's Best Glucosamine, Chondroitin, MSM With OptiMSM

Glucosamine, Chondroitin, MSM With OptiMSM by Doctor's Best consists exclusively of pure MSM, glucosamine, and chondroitin, all of which have been included in their optimal doses to produce maximum results safely. This makes it ideal for people who want supplements that don't contain anything else.

As a result, the supplement can improve joint health, structure, function, and flexibility, boost the growth and strength of the bones and cartilage, and combat arthritis and joint pain. It is also one of the more reasonably priced joint supplements, gluten-free, and offers benefits for hair and nails.

However, we must point out that using so few ingredients limits the range of effects it can produce. As a result, it will not benefit your joint health in nearly as many ways as the previous joint supplements we have examined.

Ingredients: glucosamine sulfate, chondroitin sulfate, MSM, gelatine, microcrystalline cellulose, magnesium salts, and silicon dioxide

Pros

• Contains potent doses of both glucosamine and chondroitin, as well as MSM
• Very reasonably priced
• Gluten-free

Cons

• Using so few ingredients will not benefit joint health in many ways as more diverse supplements.

Conclusion

Glucosamine, Chondroitin, MSM With OptiMSM by Doctor's Best is an excellent option for people who are solely interested in taking glucosamine, chondroitin, and the MSM they are usually paired with. Just don't expect it to produce the same range of benefits that the more diverse supplements can.

Solgar Glucosamine, Hyaluronic Acid, Chondroitin, MSM - Best With Hyaluronic Acid

Solgar Glucosamine, Hyaluronic Acid, Chondroitin, and MSM is a non-GMO, shellfish, and gluten-free supplement designed to improve joint health, flexibility, and range of motion without costing a fortune. It primarily uses the same ingredients as the other supplements we have seen, but there are two new ones.

Perhaps the most notable of these is hyaluronic acid (hyaluronan). A polysaccharide best known for its effects on the skin and eyes, it is also instrumental in joint supplements. It can boost cartilage growth and joint cushioning, reducing pain and repairing joint damage.

However, the other new ingredient, type ii collagen (seemingly snuck in), only provides minimal benefits while making the supplement unsuitable for certain people as it comes from cows. The dosages are relatively low, while each of the three tablets you take in a serving is quite large.

Ingredients: shellfish-free glucosamine hydrochloride, chondroitin sulfate, MSM, and BioCell Collagen II (undenatured type ii collagen, chondroitin sulfate, and hyaluronic acid)

Pros

• It contains high-quality, shellfish-free glucosamine and chondroitin
• One of the most reasonably priced and readily available joint supplements
• Non-GMO and gluten and shellfish-free

Cons

• It contains bovine collagen, even though the product label makes it appear vegan.
• The ingredient dosages are lower than those commonly found in many similar supplements.
• Some people have complained that the tablets are too large

Conclusion

Solgar Glucosamine, Hyaluronic Acid, Chondroitin, and MSM are some of the best supplements that combine glucosamine, chondroitin, and hyaluronan. That said, the glucosamine and chondroitin doses in these supplements will be less effective than in the other supplements we have seen.

Vimerson Health Vegan Glucosamine Chondroitin MSM & Burdock Root

Vimerson Health Vegan Glucosamine Chondroitin MSM & Burdock Root is unique among joint health supplements that contain glucosamine and chondroitin. It is entirely vegan, and research shows that these two ingredients usually come from animal sources.

Here though, the glucosamine comes from a fungus called Aspergillus niger, and they use a synthetic form of chondroitin called phytodroitin, which is produced in a lab. The MSM is always plant-based, and burdock root extract is one of the best sources of omega-3 fatty acids for vegans.

Therefore, it can boost joint mobility, lubrication, health, and pain levels. However, we must mention that there is limited evidence on vegan glucosamine and chondroitin sources, so we do not know what effects they produce. Most ingredients' doses are so high that they could cause side effects.

Ingredients: vegan glucosamine sulfate sodium, vegan MSM, burdock root 4:1 extract, phytodroitin (vegan chondroitin)

Pros

• One of the top joint health supplements for vegans or people with shellfish allergies
• Research shows that most of its ingredients help with joint pain and other health issues.
• One of the most reasonably priced joint health supplements

Cons

• There is limited evidence to show the full effects of the vegan form of chondroitin.
• Some of the ingredient's dosages are so high they could cause side effects

Conclusion

Vimerson Health Vegan Glucosamine Chondroitin MSM & Burdock Root is one of the vegans' best joint health supplements. You need to know the doses and amount of evidence on the vegan form of chondroitin, which means it may not be as safe or effective as some of the other supplements we have seen.

Nuzena Joint Support + - Best For Rheumatoid Arthritis

Nuzena Joint Support + is a joint supplement free from GMOs, heavy metals, hormones, gluten, and sugar with a very reasonable price tag. It is an excellent option for people interested in taking glucosamine and chondroitin but shopping on a tight budget.

The anti-inflammatory properties of some of its ingredients, especially quercetin, also mean it is a perfect option for people who suffer from rheumatoid arthritis pain and symptoms. It can combat the symptoms that the condition can cause and even help to repair any damage, especially knee damage.

That said, many of its ingredients are pretty low-dose, so it may not be of much use to people who do not have rheumatoid arthritis. The presence of quercetin also means it is not suitable for people who are taking blood thinners.

Ingredients: MSM, boswellia extract, bromelain, turmeric, glucosamine sulfate, chondroitin sulfate, quercetin, and methionine

Pros

• The combination of ingredients it uses are all proven to provide joint pain relief.
• One of the cheapest, most widely available joint supplements
• Ideal for people who suffer from rheumatoid arthritis

Cons

• Besides glucosamine, all its ingredients are present in much lower doses than the optimal.
• It may not be suitable for use by people taking blood thinners

Conclusion

Nuzena Joint Support + boasts a combination of ingredients and price, making it a good option for people with rheumatoid arthritis (especially in the knee) or who are shopping on a budget. It is a shame that its limitations mean it will only produce a modest benefit for everyone else.

Physio Flex Pro - Best For Knee Osteoarthritis

Physio Flex Pro is a supplement designed to help prevent or treat the pain and symptoms associated with osteoarthritis. It is best known for its ability to combat knee osteoarthritis, the most common kind, but it can also effectively combat osteoarthritis in other joints.

It achieves this by including a potent dose of selenium in every serving, which integrative health studies show is very effective in combatting osteoarthritis. It then combines this with other ingredients that combat osteoarthritis and knee pain.

Unfortunately, it is also one of the most expensive supplements, and some ingredient dosages are too low to produce their expected effects. This means it is unsuitable for people shopping on a budget or battling issues other than osteoarthritis or knee pain.

Ingredients: glucosamine HCL, chondroitin sulfate, MSM, selenium, bromelain, ginger extract, turmeric extract, and black pepper fruit extract

Pros

• It is specifically designed to prevent or treat osteoarthritis symptoms and knee pain.
• It will not cause any side effects
• It can reduce joint discomfort and stiffness and repair damage

Cons

• One of the most expensive supplements of its kind
• Of very little use to people who do not have osteoarthritis

Conclusion

If you want to take glucosamine and chondroitin to combat osteoarthritis or knee pain, Physio Flex Pro is one of the best supplements you can try, even if it is pretty pricey. For everyone else, though, you are probably better off looking at other joint health supplements.

Vitapost ProJoint Plus - Best For Psoriatic Arthritis

Vitapost ProJoint Plus is a premium joint supplement that combines high-quality ingredients to improve cartilage and joint health, elasticity, and mobility and prevent or reduce inflammation. Select ingredients in its formula, like quercetin, also make it a good option for people with psoriatic arthritis.

Add in the fact that the National Center For Health Statistics has proven all of its ingredients to work. It is third-party tested and produced in an FDA-registered facility, and it is a supplement that most people can trust.

Despite its high price tag, many of its ingredients are in lower dosages than ideal, meaning it is best reserved for people who have psoriatic arthritis. The presence of quercetin also means that it may not be suitable for use by people who are on blood-thinning medications.

Ingredients: glucosamine sulfate, chondroitin sulfate, Boswellia serrata extract, turmeric, quercetin, methionine, MSM, and bromelain

Pros

• The combination of ingredients it uses are all proven to benefit the joints.
• It is beneficial for people who suffer from psoriatic arthritis

Cons

• Very expensive
• Many of the ingredient dosages are too low
• It may not be suitable for use by people on blood-thinning medications

Conclusion

Vitapost ProJoint Plus is an excellent option for people interested in taking glucosamine and chondroitin because they have psoriatic arthritis. It is just a shame that its price and ingredient dosages make it not an excellent option for anyone else.

Puritan's Pride Triple Strength Glucosamine Chondroitin With Vitamin D

Puritan's Pride Triple Strength Glucosamine Chondroitin With Vitamin D is a preservative, sugar, milk, lactose, soy, gluten, and wheat-free supplement that can improve the health of bones, joints, and connective tissues, prevent joint issues, reduce pain, and improve joint comfort and flexibility.

It is then also very reasonably priced, which makes it a perfect option for people who are interested in taking glucosamine and chondroitin supplements but who are also shopping on a very tight budget.

Unfortunately, every ingredient in its formula has been lumped together in a single proprietary blend. This means it is impossible to determine the exact dosages present or the quality of effects that they will produce.

Ingredients: glucosamine sulfate, chondroitin sulfate, vitamin D, MSM, and Boswellia serrata extract

Pros

• All of its ingredients are proven to benefit the joints
• One of the lowest-priced supplements of its kind

Cons

• All its ingredients have their dosages and effects quality masked by a proprietary blend.

Conclusion

Puritan's Pride Triple Strength Glucosamine Chondroitin With Vitamin D will never be known as the best joint supplement on the market. However, shopping for glucosamine and chondroitin supplements on a tight budget may be the best option.

Animal Flex - Most Popular

Animal Flex is one of the most popular joint supplements. A well-known brand makes it and contains various quality ingredients that support joint and connective tissue lubrication, growth and repair, and pain reduction.

However, proprietary blends mask most ingredients' exact dosages and effects. It is pretty expensive, and the servings contain four tablets and two capsules, which is very large. It shouldn't be used by people taking blood-thinning medications, so it is unsuitable for everyone.

Ingredients: MSM, glucosamine & chondroitin sulfates, flax seed oil cetyl myristoleate, ginger root extract, turmeric root extract, Boswellia serrata extract, quercetin, bromelain, vitamin C, vitamin E, zinc, selenium, and manganese

Pros

• It mainly contains quality ingredients proven to benefit the joints
• Produced by a very well-known and popular brand

Cons

• Proprietary blends mask most ingredient dosages and effects, yet some are visibly too low.
• Some of the ingredients are unproven
• Quite expensive and not suitable for people on blood thinning medications
• It contains soy and ingredients not suitable for vegetarians
• Servings of four tablets and two capsules are too big for many

Conclusion

Animal Flex is a good option for people who prefer to use popular supplements heavily supported by word of mouth. However, like with any product, being prevalent does not necessarily mean it offers the best results or great value.

Final Thoughts on The Best Glucosamine Chondroitin Supplements In 2024

Research by the Arthritis Foundation shows that nutritional supplements with glucosamine and chondroitin can be as effective as medications from a healthcare provider while being far safer. After our research, we decided that Joint Buddy is the best supplement.

Packed with optimal doses of a comprehensive combination of high-quality ingredients backed by ample research, the Joint Buddy supplement can reduce pain, combat every form of arthritis, and improve joint health and function without seeing a doctor or putting your health at risk.

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